The candidate genes TAF5L, TCF7, PDCD1 , IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes
نویسندگان
چکیده
منابع مشابه
[Programmed cell death 1 (PDCD1) gene polymorphisms and type 1 diabetes in Chilean children].
BACKGROUND Programmed cell death 1 (PDCD-1) immune-receptor is a key element in the negative regulation of peripheral tolerance in T cells. Several polymorphisms of this gene have been described and it is linked with susceptibility to autoimmune diseases like Lupus and Multiple Sclerosis. AIM To analyze four gene polymorphisms of PDCD-1 gene and explore its possible contribution as a suscepti...
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Type 1 diabetes is an autoimmune disease with a Th1 phenotype in which insulin-producing -cells in the pancreas are destroyed. The T-cell–specific transcription factor TCF7 activates genes involved in immune regulation and is a candidate locus for genetic susceptibility to type 1 diabetes. A nonsynonymous single nucleotide polymorphism (SNP) (Pro to Thr) in the TCF7 gene, C883A, was examined in...
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ژورنال
عنوان ژورنال: BMC Medical Genetics
سال: 2007
ISSN: 1471-2350
DOI: 10.1186/1471-2350-8-71